Detecting the Potential for Consciousness in Unresponsive Patients Using the Perturbational Complexity Index.

ABSTRACT: The difficulties of behavioral evaluation of prolonged disorders of consciousness (DOC) motivate the development of brain-based diagnostic approaches. The perturbational complexity index (PCI), which measures the complexity of electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS), showed a remarkable sensitivity in detecting minimal signs of consciousness in previous studies. Here, we tested the reliability of PCI in an independently collected sample of 24 severely brain-injured patients, including 11 unresponsive wakefulness syndrome (UWS), 12 minimally conscious state (MCS) patients, and 1 emergence from MCS patient. We found that the individual maximum PCI value across stimulation sites fell within the consciousness range (i.e., was higher than PCI*, which i

SUBMITTER: Sinitsyn DO 

PROVIDER: S-EPMC7760168 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature