Transcriptional Landscape of Waddlia chondrophila Aberrant Bodies Induced by Iron Starvation.

ABSTRACT: Chronic infections caused by obligate intracellular bacteria belonging to the Chlamydiales order are related to the formation of persistent developmental forms called aberrant bodies (ABs), which undergo DNA replication without cell division. These enlarged bacteria develop and persist upon exposure to different stressful conditions such as β-lactam antibiotics, iron deprivation and interferon-γ. However, the mechanisms behind ABs biogenesis remain uncharted. Using an RNA-sequencing approach, we compared the transcriptional profile of ABs induced by iron starvation to untreated bacteria in the Chlamydia-related species Waddliachondrophila, a potential agent of abortion in ruminants and miscarriage in humans. Consistent with the growth arrest observed following i

SUBMITTER: Ardissone S 

PROVIDER: S-EPMC7760296 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature