Metabolic Alterations Related to Glioma Grading Based on Metabolomics and Lipidomics Analyses.

ABSTRACT: Gliomas are the most aggressive phenotypes of brain tumors and are classified into four grades according to the malignancy degree by the World Health Organization. Metabolic profiling can provide an overview of metabolic reprogramming at a specific stage of tumor initiation and development. Studies about metabolic alterations related to different grades of gliomas are helpful to understand the molecular mechanism for progression of glioma. In the current study, metabolomics and lipidomics analyses based on chromatography-mass spectrometry were performed on different grades of glioma tissues. Differential metabolites between glioma and para-tumor tissues were studied and used as the basis to explore metabolic alterations related to glioma grading. It was found that short-chain acylcarnitine

SUBMITTER: Yu D 

PROVIDER: S-EPMC7760389 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature