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Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus Myrothecium SP. Bzo-l062.

ABSTRACT: In the present study, four new compounds including a pair of 2-benzoyl tetrahydrofuran enantiomers, namely, (-)-1S-myrothecol (1a) and (+)-1R-myrothecol (1b), a methoxy-myrothecol racemate (2), and an azaphilone derivative, myrothin (3), were isolated along with four known compounds (4-7) from cultures of the deep-sea fungus Myrothecium sp. BZO-L062. Enantiomeric compounds 1a and 1b were separated through normal-phase chiral high-performance liquid chromatography. The absolute configurations of 1a, 1b, and 3 were assigned by ECD spectra. Among them, the new compound 1a and its enantiomer 1b exhibited anti-inflammatory activity, inhibited nitric oxide formation in lipopolysaccharide-treated RAW264.7 cells, and exhibited antioxidant activity in the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and oxygen radical absorbance capacity assays.

SUBMITTER: Lu X 

PROVIDER: S-EPMC7760613 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus <i>Myrothecium</i> SP. Bzo-l062.

Lu Xiaojie X   He Junjie J   Wu Yanhua Y   Du Na N   Li Xiaofan X   Ju Jianhua J   Hu Zhangli Z   Umezawa Kazuo K   Wang Liyan L  

Marine drugs 20201126 12

In the present study, four new compounds including a pair of 2-benzoyl tetrahydrofuran enantiomers, namely, (-)-1<i>S</i>-myrothecol (<b>1a</b>) and (+)-1<i>R</i>-myrothecol (<b>1b</b>), a methoxy-myrothecol racemate (<b>2</b>), and an azaphilone derivative, myrothin (<b>3</b>), were isolated along with four known compounds (<b>4</b>-<b>7</b>) from cultures of the deep-sea fungus <i>Myrothecium</i> sp. BZO-L062. Enantiomeric compounds <b>1a</b> and <b>1b</b> were separated through normal-phase c  ...[more]

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