Plasmodium falciparum Genetic Diversity in Panama Based on glurp, msp-1 and msp-2 Genes: Implications for Malaria Elimination in Mesoamerica.

ABSTRACT: Panamá, together with all the nations in Mesoamerica, has committed to eliminate malaria from the region by 2020. As these countries approach malaria elimination and local transmission decreases, an active molecular surveillance to identify genotypes circulating along the border areas is particularly needed to accurately infer infection origin, drug resistance and disease propagation patterns in the region. This study evaluated the genetic diversity and allele frequencies of msp-1, msp-2 and glurp genes using different molecular analyses (nested PCR, PCR-restriction fragment length polymorphism (RFLP) and sequencing) from 106 autochthonous and imported P. falciparum isolates collected from different endemic areas in Panamá between 2003 and 2019. We also explored

SUBMITTER: Santamaria AM 

PROVIDER: S-EPMC7760695 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature