Postmortem Protein Degradation as a Tool to Estimate the PMI: A Systematic Review.

ABSTRACT: Objectives: We provide a systematic review of the literature to evaluate the current research status of protein degradation-based postmortem interval (PMI) estimation. Special attention is paid to the applicability of the proposed approaches/methods in forensic routine practice. Method: A systematic review of the literature on protein degradation in tissues and organs of animals and humans was conducted. Therefore, we searched the scientific databases Pubmed and Ovid for publications until December 2019. Additional searches were performed in Google Scholar and the reference lists of eligible articles. Results: A total of 36 studies were included. This enabled us to consider the degradation pattern of over 130 proteins from 11 different tissues, studied with different methods including well

SUBMITTER: Zissler A 

PROVIDER: S-EPMC7760775 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature