Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia.

ABSTRACT: Cancer cachexia (CC) is a debilitating multifactorial syndrome, involving progressive deterioration and functional impairment of skeletal muscles. It affects about 80% of patients with advanced cancer and causes premature death. No causal therapy is available against CC. In the last few decades, our understanding of the mechanisms contributing to muscle wasting during cancer has markedly increased. Both inflammation and oxidative stress (OS) alter anabolic and catabolic signaling pathways mostly culminating with muscle depletion. Several preclinical studies have emphasized the beneficial roles of several classes of nutraceuticals and modes of physical exercise, but their efficacy in CC patients remains scant. The route of nutraceutical administration is critical to increase its bioavailabi

SUBMITTER: Aquila G 

PROVIDER: S-EPMC7760926 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature