Overview of the Anticancer Potential of the "King of Spices" Piper nigrum and Its Main Constituent Piperine.

ABSTRACT: The main limits of current anticancer therapy are relapses, chemoresistance, and toxic effects resulting from its poor selectivity towards cancer cells that severely impair a patient's quality of life. Therefore, the discovery of new anticancer drugs remains an urgent challenge. Natural products represent an excellent opportunity due to their ability to target heterogenous populations of cancer cells and regulate several key pathways involved in cancer development, and their favorable toxicological profile. Piper nigrum is one of the most popular spices in the world, with growing fame as a source of bioactive molecules with pharmacological properties. The present review aims to provide a comprehensive overview of the anticancer potential of Piper nigrum and its major active constituents-no

SUBMITTER: Turrini E 

PROVIDER: S-EPMC7761056 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature