Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview.

ABSTRACT: In recent years, there has been a growing understanding that a significant fraction of the eukaryotic proteome is intrinsically disordered, and that these conformationally dynamic proteins play a myriad of vital biological roles in both normal and pathological states. In this review, selected examples of intrinsically disordered proteins are highlighted, with particular attention for a few which are relevant in neurological disorders and in viral infection. Next, the underlying causes for the intrinsic disorder are discussed, along with computational methods used to predict whether a given amino acid sequence is likely to adopt a folded or unfolded state in the solution. Finally, biophysical methods for the analysis of intrinsically disordered proteins will be discussed, as well as the uni

SUBMITTER: Lermyte F 

PROVIDER: S-EPMC7761095 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature