The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions.

ABSTRACT: RNA editing is a relatively unexplored process in which transcribed RNA is modified at specific nucleotides before translation, adding another level of regulation of gene expression. Cephalopods use it extensively to increase the regulatory complexity of their nervous systems, and mammals use it too, but less prominently. Nevertheless, little is known about the specifics of RNA editing in most of the other clades and the relevance of RNA editing from an evolutionary perspective remains unknown. Here we analyze a key element of the editing machinery, the ADAR (adenosine deaminase acting on RNA) gene family, in an animal with a key phylogenetic position at the root of chordates: the cephalochordate amphioxus. We show, that as in cephalopods, ADAR genes in amphioxus are predominantly expresse

SUBMITTER: Zawisza-Alvarez M 

PROVIDER: S-EPMC7761149 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature