Molecular Characterization of the Burkholderia cenocepaciadcw Operon and FtsZ Interactors as New Targets for Novel Antimicrobial Design.

ABSTRACT: The worldwide spread of antimicrobial resistance highlights the need of new druggable cellular targets. The increasing knowledge of bacterial cell division suggested the potentiality of this pathway as a pool of alternative drug targets, mainly based on the essentiality of these proteins, as well as on the divergence from their eukaryotic counterparts. People suffering from cystic fibrosis are particularly challenged by the lack of antibiotic alternatives. Among the opportunistic pathogens that colonize the lungs of these patients, Burkholderia cenocepacia is a well-known multi-drug resistant bacterium, particularly difficult to treat. Here we describe the organization of its division cell wall (dcw) cluster: we found that 15 genes of the dcw operon can be transcribed as a polycistronic mR

SUBMITTER: Trespidi G 

PROVIDER: S-EPMC7761207 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature