Extracellular Vesicles as Drug Delivery Systems in Cancer.

ABSTRACT: Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Differentiated Cancer Cells (DCCs) may reverse their phenotype and gain CSC-like features to preserve tumor progression and ensure tumor survival. This strongly suggests the existence of paracrine communication within tumor cells. It is evidenced that the molecular crosstalk is at least partly mediated by Extracellular Vesicles (EVs), which are cell-derived membranous nanoparticles that contain and transport complex molecules that can affect and modify the biological behavior of distal cells and their molecular background. This ability of directional tr

SUBMITTER: Hernandez-Oller L 

PROVIDER: S-EPMC7761384 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature