A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development.

ABSTRACT: The emergence and rapid spread of Zika virus (ZIKV) on a global scale as well as the establishment of a causal link between Zika infection and congenital syndrome and neurological disorders triggered unprecedented efforts towards the development of a safe and effective Zika vaccine. Multiple vaccine platforms, including purified inactivated virus, nucleic acid vaccines, live-attenuated vaccines, and viral-vectored vaccines, have advanced to human clinical trials. In this review, we discuss the recent advances in the field of Zika vaccine development and the challenges for future clinical efficacy trials. We provide a brief overview on Zika vaccine platforms in the pipeline before summarizing the vaccine candidates in clinical trials, with a focus on recent, promising results from vaccine c

SUBMITTER: Castanha PMS 

PROVIDER: S-EPMC7761420 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature