The miRNA Content of Exosomes Released from the Glioma Microenvironment Can Affect Malignant Progression.

ABSTRACT: Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However, the timing of progression is heterogeneous. Recently, the tumor microenvironment (TME) has gained much attention either as prognostic factor or therapeutic target. Through the release of extracellular vesicles, the TME contributes to tumor progression by transferring bioactive molecules such as microRNA. The aim of the study was to take advantage of glioma-associated stem cells (GASC), an in vitro model of the glioma microenvironment endowed with a prognostic significance, and their released exosomes, to investigate the possible role of exosome miRNAs in favoring the anaplastic transformation of LGG. Therefore, by deep sequencing, we

SUBMITTER: Caponnetto F 

PROVIDER: S-EPMC7761654 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature