Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women.

ABSTRACT:

Background

Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy could potentially be applied to elucidate the molecular basis of the adverse effects of gestational weight gain (GWG) and postpartum weight loss (WL) on future risks for cardiovascular disease (CVD) and other chronic diseases.

Methods

Biofluid samples were collected from 114 ethnically diverse pregnant women with body mass index (BMI) between 25 and 40 kg/m² from Chicago (US), as part of a randomized lifestyle intervention trial (Maternal Offspring Metabolics: Family I

SUBMITTER: Lau CE 

PROVIDER: S-EPMC7761920 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature