A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes.

ABSTRACT: Tinnitus patients can present with various characteristics, such as those related to the tinnitus perception, symptom severity, and pattern of comorbidities. It is speculated that this phenotypic heterogeneity is associated with differences in the underlying pathophysiology and personal reaction to the condition. However, there is as yet no established protocol for tinnitus profiling or subtyping, hindering progress in treatment development. This review summarizes data on variables that have been used in studies investigating phenotypic differences in subgroups of tinnitus, including variables used to both define and compare subgroups. A PubMed search led to the identification of 64 eligible articles. In most studies, variables for subgrouping were chosen by the researchers (hypothesis-dri

SUBMITTER: Genitsaridi E 

PROVIDER: S-EPMC7762072 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature