Treatment of Heart Failure Patients with Anxiolytics Is Associated with Adverse Outcomes, with and without Depression.

ABSTRACT: Few studies have evaluated the effect of pharmacologic treatment of anxiety on outcomes in heart failure (HF) patients. This study examined the impact of treatment with anxiolytics on clinical outcomes in a real-world sample of HF patients with and without depression. Patients diagnosed with HF were retrieved from a large HMO database. Patients prescribed anxiolytic medication and patients diagnosed with depression and/or prescribed anti-depressant medication were followed for cardiac-related hospitalizations and death. The study cohort included 6293 HF patients. Treatment with anxiolytics was associated with decreased one-year survival compared to untreated individuals, with a greater reduction in survival seen in patients diagnosed with depression and/or treated with anti-depressants. Mu

SUBMITTER: Zwas DR 

PROVIDER: S-EPMC7762354 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature