The Gut Microbiome, Aging, and Longevity: A Systematic Review.

ABSTRACT: Aging is determined by complex interactions among genetic and environmental factors. Increasing evidence suggests that the gut microbiome lies at the core of many age-associated changes, including immune system dysregulation and susceptibility to diseases. The gut microbiota undergoes extensive changes across the lifespan, and age-related processes may influence the gut microbiota and its related metabolic alterations. The aim of this systematic review was to summarize the current literature on aging-associated alterations in diversity, composition, and functional features of the gut microbiota. We identified 27 empirical human studies of normal and successful aging suitable for inclusion. Alpha diversity of microbial taxa, functional pathways, and metabolites was higher in older adults, p

SUBMITTER: Badal VD 

PROVIDER: S-EPMC7762384 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature