Autophagy in Osteosarcoma Cancer Stem Cells Is  Critical Process which Can Be Targeted by the Antipsychotic Drug Thioridazine.

ABSTRACT: Cancer stem cells (CSCs) represent a minor population of cancer cells with stem cell-like properties which are able to fuel tumor growth and resist conventional treatments. Autophagy has been described to be upregulated in some CSCs and to play a crucial role by maintaining stem features and promoting resistance to both hostile microenvironments and treatments. Osteosarcoma (OS) is an aggressive bone cancer which mainly affects children and adolescents and autophagy in OS CSCs has been poorly studied. However, this is a very interesting case because autophagy is often deregulated in this cancer. In the present work, we used two OS cell lines showing different autophagy capacities to isolate CSC-enriched populations and to analyze the autophagy in basal and nutrient-deprived conditions. Our

SUBMITTER: Camuzard O 

PROVIDER: S-EPMC7762415 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature