Female-specific effects of the catechol-O-methyl transferase Val¹⁵⁸Met gene polymorphism on working memory-related brain function.

ABSTRACT: The catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism has been associated with working memory (WM) in many studies, but the results have not been consistent. One plausible explanation is sex-specific effects of this polymorphism as reported in several studies. The current study aimed to explore the sex-specific effects of the COMT Val¹⁵⁸Met polymorphism on WM-related brain function in an elderly sample. We found that Val homozygotes outperformed Met allele carriers on the backward digit span subtest for both males and females. The triangular part of the left inferior frontal gyrus and the left inferior temporal gyrus exhibited higher activation in Met allele carriers compared with Val homozygotes during the n-back task, while the background func

SUBMITTER: Fan J 

PROVIDER: S-EPMC7762470 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature