Molecular subtypes based on DNA promoter methylation predict prognosis in lung adenocarcinoma patients.

ABSTRACT:

Background

The heterogeneity of lung adenocarcinoma (LADC) makes the early diagnosis and treatment of the disease difficult. Gene silencing of DNA methylation is an important mechanism of tumorigenesis. A combination of methylation and clinical features can improve the classification of LADC heterogeneity.

Results

We investigated the prognostic significance of 335 specimen subgroups of Lung adenocarcinoma based on the DNA methylation level. The differences in DNA methylation levels were related to the TNM stage classification, age, gender, and prognostic values. Seven subtypes were determined using 774 CpG sites that significantly affected the survival rate based on the consensus clustering. Finally, we constructed a prognostic model that performed well and further verified

SUBMITTER: Shi S 

PROVIDER: S-EPMC7762488 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature