Interrogation of <i>IDH1</i> Status in Gliomas by Fourier Transform Infrared Spectroscopy.

ABSTRACT: Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are found in a high proportion of diffuse gliomas. The presence of the IDH1 mutation is a valuable diagnostic, prognostic and predictive biomarker for the management of patients with glial tumours. Techniques involving vibrational spectroscopy, e.g., Fourier transform infrared (FTIR) spectroscopy, have previously demonstrated analytical capabilities for cancer detection, and have the potential to contribute to diagnostics. The implementation of FTIR microspectroscopy during surgical biopsy could present a fast, label-free method for molecular genetic classification. For example, the rapid determination of IDH1 status in a patient with a glioma diagnosis could inform intra-operative decision-making between alternat

SUBMITTER: Cameron JM 

PROVIDER: S-EPMC7762605 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature