A Comparison of Gene Expression Changes in the Blood of Individuals Consuming Diets Supplemented with Olives, Nuts or Long-Chain Omega-3 Fatty Acids.

ABSTRACT:

Background

The Mediterranean diet, which is rich in olive oil, nuts, and fish, is considered healthy and may reduce the risk of chronic diseases.

Methods

Here, we compared the transcriptome from the blood of subjects with diets supplemented with olives, nuts, or long-chain omega-3 fatty acids and identified the genes differentially expressed. The dietary genes obtained were subjected to network analysis to determine the main pathways, as well as the transcription factors and microRNA interaction network to elucidate their regulation. Finally, a gene-associated disease interaction network was performed.

Results

We identified several genes whose expression is altered after the intake of components of the Mediterranean diets compared to controls. These genes were associa

SUBMITTER: Bottero V 

PROVIDER: S-EPMC7762614 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature