In silico study of the potential interactions of 4'-acetamidechalcones with protein targets in SARS-CoV-2.

ABSTRACT: The sanitary emergency generated by the pandemic COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 20 million people were reported with the infection. Of these, more than 740,000 died. In view of the situation, strategies involving the development of new antiviral molecules are extremely important. The present work evaluated, through molecular docking assays, the interactions of 4'-acetamidechalcones with enzymatic and structural targets of SARS-CoV-2 and with the host's ACE2, which is recognized by the virus, facilitating its entry into cells. Therefore, it was observed that, regarding the interactions of ch

SUBMITTER: Q Almeida-Neto FW 

PROVIDER: S-EPMC7762712 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature