Epothilones Improve Axonal Growth and Motor Outcomes after Stroke in the Adult Mammalian CNS.

ABSTRACT: Stroke leads to the degeneration of short-range and long-range axonal connections emanating from peri-infarct tissue, but it also induces novel axonal projections. However, this regeneration is hampered by growth-inhibitory properties of peri-infarct tissue and fibrotic scarring. Here, we tested the effects of epothilone B and epothilone D, FDA-approved microtubule-stabilizing drugs that are powerful modulators of axonal growth and scar formation, on neuroplasticity and motor outcomes in a photothrombotic mouse model of cortical stroke. We find that both drugs, when administered systemically 1 and 15 days after stroke, augment novel peri-infarct projections connecting the peri-infarct motor cortex with neighboring areas. Both drugs also increase the magnitude of long-range motor projection

SUBMITTER: Kugler C 

PROVIDER: S-EPMC7762779 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature