Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis.

ABSTRACT:

Introduction

Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood and few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression is reduced in OA patients' synovia. Here we examine the profile of TRPC5 in DRG and involvement in murine models of OA.

Design

TRPC5 KO mice were subjected to partial meniscectomy (PMNX) or injected with monoiodoacetate (MIA) and pain-related behaviours were determined. Knee joint pathological scores were analysed and gene expression changes in ipsilateral synovium and dorsal root ganglia (DRG) determined. c-Fos protein expression in the ipsilateral dorsal horn of the spinal cord was quantified.

Results

TRPC5 KO mice developed a discrete en

SUBMITTER: de Sousa Valente J 

PROVIDER: S-EPMC7762818 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature