Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine.

ABSTRACT: Cortical recordings of task-induced oscillations following subanaesthetic ketamine administration demonstrate alterations in amplitude, including increases at high-frequencies (gamma) and reductions at low frequencies (theta, alpha). To investigate the population-level interactions underlying these changes, we implemented a thalamo-cortical model (TCM) capable of recapitulating broadband spectral responses. Compared with an existing cortex-only 4-population model, Bayesian Model Selection preferred the TCM. The model was able to accurately and significantly recapitulate ketamine-induced reductions in alpha amplitude and increases in gamma amplitude. Parameter analysis revealed no change in receptor time-constants but significant increases in select synaptic connectivity with ketamine. Sign

SUBMITTER: Shaw AD 

PROVIDER: S-EPMC7762824 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature