Genomic Epidemiology of Carbapenemase Producing <i>Klebsiella pneumoniae</i> Strains at a Northern Portuguese Hospital Enables the Detection of a Misidentified <i>Klebsiella variicola</i> KPC-3 Producing Strain.

ABSTRACT: The evolutionary epidemiology, resistome, virulome and mobilome of thirty-one multidrug resistant Klebsiella pneumoniae clinical isolates from the northern Vila Real region of Portugal were characterized using whole-genome sequencing and bioinformatic analysis. The genomic population structure was dominated by two main sequence types (STs): ST147 (n = 17; 54.8%) and ST15 (n = 6; 19.4%) comprising four distinct genomic clusters. Two main carbapenemase coding genes were detected (bla_KPC-3 and bla_OXA-48) along with additional extended-spectrum β-lactamase coding loci (bla_CTX-M-15, bla_SHV-12, bla_SHV-27, and bla_SHV-187). Moreover, whole genome sequencing enabled the i

SUBMITTER: Perdigao J 

PROVIDER: S-EPMC7763156 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature