Development and Field Validation of Lidocaine-Loaded Castration Bands for Bovine Pain Mitigation.

ABSTRACT: Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding. Despite the various benefits of castration, all methods produce pain and distress. Castration by banding is simple, inexpensive, produces fewer complications, and can be performed in a high-throughput manner. Because lidocaine, a local anesthetic, can be delivered to trauma sites topically, we have formulated lidocaine-loaded castration bands (LLBs) to deliver local pain relief to calves during banded castration. The initial lidocaine content of three band types developed was between 80 and 200 mg per band. The transfer kinetics of lidocaine into tissue was determined in vitro, indicating a rapid release for the first 30 min, fol

SUBMITTER: Saville JW 

PROVIDER: S-EPMC7763166 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature