Cell Sheets Restore Secretory Function in Wounded Mouse Submandibular Glands.

ABSTRACT: Thermoresponsive cell culture plates release cells as confluent living sheets in response to small changes in temperature, with recovered cell sheets retaining functional extracellular matrix proteins and tight junctions, both of which indicate formation of intact and functional tissue. Our recent studies demonstrated that cell sheets are highly effective in promoting mouse submandibular gland (SMG) cell differentiation and recovering tissue integrity. However, these studies were performed only at early time points and extension of the observation period is needed to investigate duration of the cell sheets. Thus, the goal of this study was to demonstrate that treatment of wounded mouse SMG with cell sheets is capable of increasing salivary epithelial integrity over extended time periods. T

SUBMITTER: Dos Santos HT 

PROVIDER: S-EPMC7763220 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature