Using an Untargeted Metabolomics Approach to Identify Salivary Metabolites in Women with Breast Cancer.

ABSTRACT: Metabolic alterations are a hallmark of the malignant transformation in cancer cells, which is characterized by multiple changes in metabolic pathways that are linked to macromolecule synthesis. This study aimed to explore whether salivary metabolites could help discriminate between breast cancer patients and healthy controls. Saliva samples from 23 breast cancer patients and 35 healthy controls were subjected to untargeted metabolomics using liquid chromatography-quadrupole time-of-flight mass spectrometry and a bioinformatics tool (XCMS Online), which revealed 534 compounds, characterized by their retention time in reverse-phase liquid chromatography and by the m/z ratio detected, that were shared by the two groups. Using the METLIN database, 31 compounds that were upregulated in the bre

SUBMITTER: Xavier Assad D 

PROVIDER: S-EPMC7763953 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature