Viral Vectors as Gene Therapy Agents for Treatment of Glioblastoma.

ABSTRACT: In this review, we scrutinize the idea of using viral vectors either as cytotoxic agents or gene delivery tools for treatment of glioblastoma multiforme (GBM) in light of the experience that our laboratory has accumulated over ~20 years when using similar vectors in experimental neuroscience. We review molecular strategies and current clinical trials and argue that approaches which are based on targeting a specific biochemical pathway or a characteristic mutation are inherently prone to failure because of the high genomic instability and clonal selection characteristics of GBM. For the same reasons, attempts to develop a viral system which selectively transduces only GBM cells are also unlikely to be universally successful. One of the common gene therapy approaches is to use cytotoxic viru

SUBMITTER: Mozhei O 

PROVIDER: S-EPMC7764372 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature