Charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part I: Complexation with iodine in different solvents.

ABSTRACT: Around the world, the antibiotic azithromycin (AZM) is currently being used to treat the coronavirus disease (COVID-19) in conjunction with hydroxychloroquine or chloroquine. Investigating the chemical and physical properties of compounds used alone or in combination to combat the COVID-19 pandemic is of vital and pressing importance. The purpose of this study was to characterize the charge transfer (CT) complexation of AZM with iodine in four different solvents: CH₂Cl₂, CHCl₃, CCl₄, and C₆H₅Cl. AZM reacted with iodine at a 1:1 M ratio (AZM to I₂) in the CHCl₃ solvent and a 1:2 M ratio in the other three solvents, as evidenced by data obtained from an elemental analysis of the solid CT products and spec

SUBMITTER: Adam AMA 

PROVIDER: S-EPMC7764390 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature