Trimethyllysine: From Carnitine Biosynthesis to Epigenetics.

ABSTRACT: Trimethyllysine is an important post-translationally modified amino acid with functions in the carnitine biosynthesis and regulation of key epigenetic processes. Protein lysine methyltransferases and demethylases dynamically control protein lysine methylation, with each state of methylation changing the biophysical properties of lysine and the subsequent effect on protein function, in particular histone proteins and their central role in epigenetics. Epigenetic reader domain proteins can distinguish between different lysine methylation states and initiate downstream cellular processes upon recognition. Dysregulation of protein methylation is linked to various diseases, including cancer, inflammation, and genetic disorders. In this review, we cover biomolecular studies on the role of trimet

SUBMITTER: Maas MN 

PROVIDER: S-EPMC7764450 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature