Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile.

ABSTRACT: Asunercept (APG101) is a well-tolerated CD95-ligand inhibitor that showed promising efficacy in a prospective, single-arm phase I study in anemic, transfusion-dependent patients with low and intermediate risk myelodysplastic syndrome (MDS). In this retrospective post hoc analysis, serum levels of biomarkers were measured in study patients focusing on cytokines associated with erythropoiesis, inflammation, apoptosis, bone marrow fibrosis, and inflammasome activity. Baseline serum biomarkers were correlated with treatment response, in order to propose a hypothetical responder serum profile. After an updated median follow-up of 54 months (range 7-65), response to asunercept was associated with improved overall survival (at 3-years: 67% [95%CI 36-97] versus 13% [95%CI 0-36] in responders versu

SUBMITTER: Radujkovic A 

PROVIDER: S-EPMC7764464 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature