Near haploidization is a genomic hallmark which defines a molecular subgroup of giant cell glioblastoma.

ABSTRACT:

Background

Giant cell glioblastoma (gcGBM) is a rare histologic subtype of glioblastoma characterized by numerous bizarre multinucleate giant cells and increased reticulin deposition. Compared with conventional isocitrate dehydrogenase (IDH)-wildtype glioblastomas, gcGBMs typically occur in younger patients and are generally associated with an improved prognosis. Although prior studies of gcGBMs have shown enrichment of genetic events, such as TP53 alterations, no defining aberrations have been identified. The aim of this study was to evaluate the genomic profile of gcGBMs to facilitate more accurate diagnosis and prognostication for this entity.

Methods

Through a multi-institutional collaborative effort, we characterized 10 gcGBMs by chromosome studies, single nucleo

SUBMITTER: Baker TG 

PROVIDER: S-EPMC7764500 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature