Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.

ABSTRACT:

Background

Hypoxia is a driver of treatment resistance in glioblastoma. Antiangiogenic agents may transiently normalize blood vessels and decrease hypoxia before excessive pruning of vessels increases hypoxia. The time window of normalization is dose and time dependent. We sought to determine how VEGF blockade with bevacizumab modulates tumor vasculature and the impact that those vascular changes have on hypoxia in recurrent glioblastoma patients.

Methods

We measured tumor volume, vascular permeability (Ktrans), perfusion parameters (cerebral blood flow/volume, vessel caliber, and mean transit time), and regions of hypoxia in patients with recurrent glioblastoma before and after treatment with bevacizumab alone or with lomustine using [¹⁸F]FMISO PET-MRI. We also e

SUBMITTER: Gerstner ER 

PROVIDER: S-EPMC7764510 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature