Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion.

ABSTRACT: Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusio

SUBMITTER: Koutsamanis I 

PROVIDER: S-EPMC7764633 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature