Prenatal Multivitamin Use and MTHFR Genotype Are Associated with Newborn Cord Blood DNA Methylation.

ABSTRACT:

Background

Fetal development involves cellular differentiation and epigenetic changes-complex processes that are sensitive to environmental factors. Maternal nutrient levels during pregnancy affect development, and methylene tetrahydrofolate reductase (MTHFR) is important for processing the nutrient folate.

Hypothesis

We hypothesize that supplement intake before pregnancy and maternal genotype are associated with DNA methylation in newborns.

Methods

In the pregnancy cohort, Early Autism Risk Longitudinal Investigation (EARLI), health history, and genotype information was obtained (n = 249 families). Cord blood DNA methylation (n = 130) was measured using the Illumina HumanMethylation450k array and global DNA methylation levels were computed over 455,698 sites.

SUBMITTER: Bakulski KM 

PROVIDER: S-EPMC7764679 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature