Longitudinal Analysis of Peripheral and Colonic CD161⁺ CD4⁺ T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation.

ABSTRACT: CD161 expression on CD4⁺ T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18 without T cell receptor (TCR) stimulation. Chronic HIV-1 infection is associated with loss of the CD161⁺ CD4 T cell population, and non-human primate studies suggest that their depletion is associated with disease progression. However, the dynamics of the CD161⁺ CD4⁺ T cell population during acute HIV-1 infection remains unknown. In this study, we characterize peripheral blood CD161⁺ CD4⁺ T cells in detail, and examine how they are affected during the earliest stages of HIV-1 infection. Unbiased surface proteome screening and principal component analysis indicated tha

SUBMITTER: Lal KG 

PROVIDER: S-EPMC7764746 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature