GAS2L1 Is a Potential Biomarker of Circulating Tumor Cells in Pancreatic Cancer.

ABSTRACT: Pancreatic cancer is a malignant disease with high mortality and a dismal prognosis. Circulating tumor cell (CTC) detection and characterization have emerged as essential techniques for early detection, prognostication, and liquid biopsy in many solid malignancies. Unfortunately, due to the low EPCAM expression in pancreatic cancer CTCs, no specific marker is available to identify and isolate this rare cell population. This study analyzed single-cell RNA sequencing profiles of pancreatic CTCs from a genetically engineered mouse model (GEMM) and pancreatic cancer patients. Through dimensionality reduction analysis, murine pancreatic CTCs were grouped into three clusters with different biological functions. CLIC4 and GAS2L1 were shown to be overexpressed in pancreatic CTCs in c

SUBMITTER: Zhu L 

PROVIDER: S-EPMC7765300 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature