Subacute cannabidiol alters genome-wide DNA methylation in adult mouse hippocampus.

ABSTRACT: Use of cannabidiol (CBD), the most abundant non-psychoactive compound found in cannabis (Cannabis sativa), has recently increased as a result of widespread availability of CBD-containing products. CBD is FDA-approved for the treatment of epilepsy and exhibits anxiolytic, antipsychotic, prosocial, and other behavioral effects in animal studies and clinical trials, however, the underlying mechanisms governing these phenotypes are still being elucidated. The epigenome, particularly DNA methylation, is responsive to environmental input and can govern persistent patterns of gene regulation affecting phenotype across the life course. In order to understand the epigenomic activity of cannabidiol exposure in the adult brain, 12-week-old male wild-type a/a Agouti viable yellow (A^vy ) mic

SUBMITTER: Wanner NM 

PROVIDER: S-EPMC7765463 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature