Identification of Novel Potential Genes Involved in Cancer by Integrated Comparative Analyses.

ABSTRACT: The main hallmarks of cancer diseases are the evasion of programmed cell death, uncontrolled cell division, and the ability to invade adjacent tissues. The explosion of omics technologies offers challenging opportunities to identify molecular agents and processes that may play relevant roles in cancer. They can support comparative investigations, in one or multiple experiments, exploiting evidence from one or multiple species. Here, we analyzed gene expression data from induction of programmed cell death and stress response in Homo sapiens and compared the results with Saccharomyces cerevisiae gene expression during the response to cell death. The aim was to identify conserved candidate genes associated with Homo sapiens cell death, favored by crosslinks based on orthology relationships be

SUBMITTER: Monticolo F 

PROVIDER: S-EPMC7765469 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature