Dimethandrolone Undecanoate, a Novel, Nonaromatizable Androgen, Increases P1NP in Healthy Men Over 28 Days.

ABSTRACT:

Context

Dimethandrolone undecanoate (DMAU) is being developed as a male contraceptive. Daily oral administration of DMAU, a potent androgen that is not aromatized, markedly suppresses serum testosterone (T) and estradiol (E2) in healthy men. E2 deficiency can increase bone resorption in men.

Objective

This work aimed to assess changes in bone turnover markers with DMAU administration in a 28-day study.

Design

A randomized, double-blind, placebo-controlled study was conducted.

Setting

This study took place at 2 academic medical centers.

Participants

Healthy men, age 18 to50 years (n = 81), participated.

Intervention

Men received 0, 100, 200, or 400 mg of oral DMAU for 28 days. Serum C-terminal telopeptide of type I collagen (CTX; bone resorption ma

SUBMITTER: Thirumalai A 

PROVIDER: S-EPMC7765650 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature