Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.

ABSTRACT:

Context

Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity.

Objective

To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies.

Design

We performed a genome-wide meta-analysis for beta-cell glucose sensitivity in subjects with type 2 diabetes and nondiabetic subjects from 6 independent cohorts (n = 5706). Beta-cell glucose sensitivity was calculated from mixed meal and oral glucose tolerance tests, and its associations between k

SUBMITTER: Deshmukh HA 

PROVIDER: S-EPMC7765651 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature