Association of Acute Kidney Injury with Cardiovascular Events and Death in Systolic Blood Pressure Intervention Trial.

ABSTRACT:

Rationale and objective

In the Systolic Blood Pressure Intervention Trial, the possible relationships between acute kidney injury (AKI) and risk of major cardiovascular events and death are not known.

Study design

Post hoc analysis of a multicenter, randomized, controlled, open-label clinical trial.

Setting and participants

Hypertensive adults without diabetes who were ≥50 years of age with prior cardiovascular disease, chronic kidney disease (CKD), 10-year Framingham risk score > 15%, or age > 75 years were assigned to a systolic blood pressure target of < 120 mm Hg (intensive) or < 140 mm Hg (standard).

Predictor

AKI episodes.

Outcomes

The primary outcome was a composite of myocardial infarction, acute coronary syndrome, stroke, decompensated heart fai

SUBMITTER: Dieter BP 

PROVIDER: S-EPMC7765707 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature