Translating genomic insights into cardiovascular medicine: Opportunities and challenges of CRISPR-Cas9.

ABSTRACT: The growing appreciation of human genetics and genomics in cardiovascular disease (CVD) accompanied by the technological breakthroughs in genome editing, particularly the CRISPR-Cas9 technologies, has presented an unprecedented opportunity to explore the application of genome editing in cardiovascular medicine. The ever-growing genome editing toolbox includes an assortment of CRISPR-Cas systems with increasing efficiency, precision, flexibility, and targeting capacity. Over the past decade, the advent of large-scale genotyping technologies and genome-wide association studies (GWAS) has provided numerous genotype-phenotype associations for diseases with complex traits. Notably, a growing number of loss-of-function mutations have been associated with favorable CVD risk-factor profiles that m

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7765739 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature