Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates.

ABSTRACT: Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not known. In this study, we sought to identify factors that influence fetal TL. A total of 578 mother-newborn pairs were included for TL analysis. TL was measured in genomic DNA extracted from cord blood samples using quantitative PCR. The clinical factors examined at enrollment included the following intrauterine environmental factors: maternal age, assisted reproductive technology (ART) used, body mass index (BMI), gestational diabetes mellitus (GDM), maternal stress, smoking,

SUBMITTER: Minamoto T 

PROVIDER: S-EPMC7766074 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature