Characterization of Sensorineural Hearing Loss in Children with Alport Syndrome.

ABSTRACT: Most adults with Alport syndrome (AS) suffer from progressive sensorineural hearing loss. However, little is known about the early characteristics of hearing loss in children with AS. As a part of the EARLY PRO-TECT Alport trial, this study was the first clinical trial ever to investigate hearing loss in children with AS over a timespan of up to six years Nine of 51 children (18%) had hearing impairment. Audiograms were divided into three age groups: in the 5-9-year-olds, the 4-pure tone average (4PTA) was 8.9 decibel (dB) (n = 15) in those with normal hearing and 43.8 dB (n = 2, 12%) in those with hearing impairment. Among the 10-13-year-olds, 4PTA was 4.8 dB (healthy, n = 12) and 41.4 dB (hearing impaired, n = 6.33%). For the 14-20-year-olds, the 4PTA was 7.0 dB (healthy; n = 9) and 48.2

SUBMITTER: Boeckhaus J 

PROVIDER: S-EPMC7766141 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature