Utility of Circulating Tumor DNA in Different Clinical Scenarios of Breast Cancer.

ABSTRACT: Breast cancer is a complex disease whose molecular mechanisms are not completely understood. Developing target therapies is a promising approach. Therefore, understanding the biological behavior of the tumor is a challenge. Tissue biopsy in the metastatic setting remains the standard method for diagnosis. Nevertheless, it has been associated with some disadvantages: It is an invasive procedure, it may not represent tumor heterogeneity, and it does not allow for treatment efficacy to be assessed or early recurrences to be detected. Analysis of circulating tumor DNA (ctDNA) may help to overcome this as it is a non-invasive method of monitoring the disease. In early-stage disease, it can detect early recurrences and monitor tumors' genomic profiles, identifying the emergence of new genetic al

SUBMITTER: Mesquita A 

PROVIDER: S-EPMC7766337 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature